MicroRNAs

Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness
Vascular stiffness plays a key role in the pathogenesis of hypertension. Recent studies indicate that the age-associated reduction in …
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Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair
Translin-associated protein X (TSNAX), also called trax, was first identified as a protein that interacts with translin. Subsequent …
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Multiple Pathways Mediate MicroRNA Degradation: Focus on the Translin/Trax RNase Complex
The discovery of the microRNA system has revolutionized our understanding of translational control. Furthermore, growing appreciation …
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Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity
As microRNAs silence translation, rapid reversal of this process has emerged as an attractive mechanism for driving de novo protein …
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