MicroRNA degradation

Degradation of premature-mir-181b by the translin/trax rnase increases vascular smooth muscle cell stiffness
In this study, we have used vascular smooth muscle cell cultures to demonstrate that TN/TX activation elicits cell stiffening by decreasing miR-181b levels and promoting TGF-β signaling. Furthermore, genetic inactivation of the TN/TX RNase in vivo blocks HSW-induced or ageassociated aortic stiffening.
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Multiple Pathways Mediate MicroRNA Degradation: Focus on the Translin/Trax RNase Complex
The discovery of the microRNA system has revolutionized our understanding of translational control. Furthermore, growing appreciation …
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