"aorta"

Degradation of premature-mir-181b by the translin/trax rnase increases vascular smooth muscle cell stiffness

In this study, we have used vascular smooth muscle cell cultures to demonstrate that TN/TX activation elicits cell stiffening by decreasing miR-181b levels and promoting TGF-β signaling. Furthermore, genetic inactivation of the TN/TX RNase in vivo blocks HSW-induced or ageassociated aortic stiffening.

Eric Tuday, Mitsunori Nakano, Kei Akiyoshi, Xiuping Fu, Aparna P. Shah, Atsushi Yamaguchi, Charles Steenbergen, Lakshmi Santhanam, Steven S. An, Dan Berkowitz, Jay M. Baraban, Samarjit Das

Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness

Vascular stiffness plays a key role in the pathogenesis of hypertension. Recent studies indicate that the age-associated reduction in …

Eric Tuday, Yohei Nomura, Deepa Ruhela, Mitsunori Nakano, Xiuping Fu, Aparna Shah, Barbara Roman, Atsushi Yamaguchi, Steven S. An, Charles Steenbergen, Jay M. Baraban, Dan E. Berkowitz, Samarjit Das