Animals

Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness
Vascular stiffness plays a key role in the pathogenesis of hypertension. Recent studies indicate that the age-associated reduction in …
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Trax: A versatile signaling protein plays key roles in synaptic plasticity and DNA repair
Translin-associated protein X (TSNAX), also called trax, was first identified as a protein that interacts with translin. Subsequent …
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Multiple Pathways Mediate MicroRNA Degradation: Focus on the Translin/Trax RNase Complex
The discovery of the microRNA system has revolutionized our understanding of translational control. Furthermore, growing appreciation …
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Role of TrkB in the anxiolytic-like and antidepressant-like effects of vagal nerve stimulation: Comparison with desipramine
A current hypothesis regarding the mechanism of antidepressant (AD) action suggests the involvement of brain-derived neurotrophic …
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Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity
As microRNAs silence translation, rapid reversal of this process has emerged as an attractive mechanism for driving de novo protein …
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Influence of acute or chronic administration of ovarian hormones on the effects of desipramine in the forced swim test in female rats
RATIONALE: Gender may influence antidepressant (AD) treatment outcome. In order to address this preclinically, the potential effects of …
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Modification of the behavioral effects of morphine in rats by serotonin 5-HT₁A and 5-HT₂A receptor agonists: antinociception, drug discrimination, and locomotor activity
RATIONALE: Indirect-acting serotonin (5-HT) receptor agonists can enhance the antinociceptive effects of morphine; however, the …
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Effects of chronic plus acute prolonged stress on measures of coping style, anxiety, and evoked HPA-axis reactivity
Exposure to psychological trauma is the precipitating factor for PTSD. In addition, a history of chronic or traumatic stress exposure …
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Serotonergic and noradrenergic pathways are required for the anxiolytic-like and antidepressant-like behavioral effects of repeated vagal nerve stimulation in rats
BACKGROUND: Vagal nerve stimulation (VNS) is used for treatment-refractory depression, but there are few preclinical studies of its …
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