Article-Journal

Trax: a versatile signaling protein plays key roles in synaptic plasticity and DNA repair
Translin-associated protein X (TSNAX), also called trax, was first identified as a protein that interacts with translin. Subsequent …
Yijuang Chern, Ting Chien, Xiuping Fu, Aparna P Shah, Ted Abel, Jay M Baraban
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Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity
As microRNAs silence translation, rapid reversal of this process has emerged as an attractive mechanism for driving de novo protein …
Xiuping Fu, Aparna Shah, Jay M Baraban
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Role of TrkB in the anxiolytic-like and antidepressant-like effects of vagal nerve stimulation: Comparison with desipramine
A current hypothesis regarding the mechanism of antidepressant (AD) action suggests the involvement of brain-derived neurotrophic …
Aparna P Shah, Flavia R Carreno, Haishan Wu, Yunmi a Chung, Alan Frazer
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Influence of acute or chronic administration of ovarian hormones on the effects of desipramine in the forced swim test in female rats
RATIONALE:
Gender may influence antidepressant (AD) treatment outcome. In order to address this preclinically, the potential effects of …
Aparna Shah, Alan Frazer
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Therapeutic modalities for treatment resistant depression: focus on vagal nerve stimulation and ketamine
Treatment resistant depression (TRD) is a global health concern affecting a large proportion of depressed patients who then require …
Aparna Shah, Flavia Regina Carreno, Alan Frazer
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Modification of the behavioral effects of morphine in rats by serotonin (5-HT) 1A and 5-HT 2A receptor agonists: antinociception, drug discrimination, and locomotor activity
RATIONALE:
Indirect-acting serotonin (5-HT) receptor agonists can enhance the antinociceptive effects of morphine; however, the …
Jun-Xu Li, Aparna P Shah, Sunny K Patel, Kenner C Rice, Charles P France
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Effects of chronic plus acute prolonged stress on measures of coping style, anxiety, and evoked HPA-axis reactivity
Exposure to psychological trauma is the precipitating factor for PTSD. In addition, a history of chronic or traumatic stress exposure …
Megan K Roth, Brian Bingham, Aparna Shah, Ankur Joshi, Alan Frazer, Randy Strong, David a Morilak
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Serotonergic and noradrenergic pathways are required for the anxiolytic-like and antidepressant-like behavioral effects of repeated vagal nerve stimulation in rats
BACKGROUND:
Vagal nerve stimulation (VNS) is used for treatment-refractory depression, but there are few preclinical studies of its …
Havan Furmaga, Aparna Shah, Alan Frazer
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